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Cancer Stem Cell News
Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.
CD271 mRNA/hnRNPA2B1 Complex Promotes Proliferation and Stemness in Oral and Head and Neck Squamous Cell Carcinoma
[Cancer Science] The authors show edthat CD271 mRNA, but not CD271 protein, facilitates spheroid cell proliferation. They established CD271−/− cells lacking both mRNA and protein of CD271, as well as CD271 protein knockout cells lacking only CD271 protein, from hypopharyngeal and oral squamous cell carcinoma lines.
Stem Cells Derived Exosomes as Biological Nano Carriers for VCR Sulfate for Treating Breast Cancer Stem Cells
[Scientific Reports] Investigators isolated exosomes (Exos) from MSCs, and using probe-sonication approach loaded them with vincristine (VCR) sulfate. Using SRB assay, the cytotoxicity of VCR sulfate-Exo was assessed in T47D breast cancer cells, and the results were contrasted with those of free VCR sulfate.
Iron Metabolism: Backfire of Cancer Cell Stemness and Therapeutic Modalities
[Cancer Cell International] Investigators explored recent advances in iron metabolism in CSCs, conventional cancer therapies targeting iron biochemistry, therapeutic resistance in these cells, and potential treatment options that could overcome them.
Circ-0075305 Hinders Gastric Cancer Stem Cells by Indirectly Disrupting TCF4–β-Catenin Complex and Downregulation of SOX9
[Communications Biology] In vitro and in vivo experiments confirmed that overexpression of Circ-0075305 could effectively reduce stem cell-like properties and enhanced the sensitivity of gastric cancer cells to Oxaliplatin compared with the control group.
Cancer Stem-Like Cells in Uveal Melanoma: Novel Insights and Therapeutic Implications
[Biochimica Et Biophysica Acta-Reviews On Cancer] Scientists discuss the state of the art of CSC biology and their potential exploitation as therapeutic target in uveal melanoma.
WNT5B Drives Osteosarcoma Stemness, Chemoresistance, and Metastasis
[Clinical and Translational Medicine] Using tumor-spheroids to model cancer stem-like cells, investigators performed qPCR, immunoblotting, and immunofluorescence to monitor changes in gene and protein expression.
Aberrant Activation of TGF-β/ROCK1 Enhances Stemness during Prostatic Stromal Hyperplasia
[Cell Communication and Signaling] Investigators demonstrated that the aberrant activation of transforming growth factor β (TGF-β)/Rho kinase 1 (ROCK1) increased the stemness of benign prostatic hyperplasia (BPH) tissue by recruiting mesenchymal stem cells, indicating the important role of embryonic reawakening in BPH.
TRIM58 Downregulation Maintains Stemness via MYH9-GRK3-YAP Axis Activation in Triple-Negative Breast Cancer Stem Cells
[Cancer Gene Therapy] Investigators reported that TRIM58 was underexpressed in TNBC tissues and cells compared to adjacent mucosa tissue, and its downregulation was significantly associated with shorter survival.
Expression of Fascin-1 and Its Diagnostic Value in Liver Cancer
[Scientific Reports] Researchers analyzed the expression level of FSCN1 protein in liver cancer tissues and explored its diagnostic and application value in differentiating between HCC and intrahepatic cholangiocarcinom
Kupffer Cell Diversity Maintains Liver Function in Alcohol-Associated Liver Disease
[Hepatology] Scientists used a Western Diet Alcohol mouse model of alcohol-associated liver disease (ALD) to examine the hepatic myeloid cell compartment by scRNA seq and targeted Kupffer cell ablation to understand the diversity and function of liver macrophages in ALD.
Roles and Therapeutic Targeting of Dendritic Cells in Liver Fibrosis
[Journal Of Drug Targeting] The authors describe the process of fibrogenesis, and the phenotypic and functional characteristics of dendritic cells in the liver.
Multimodal Decoding of Human Liver Regeneration
[Nature] The authors uncovered a novel ANXA2+ migratory hepatocyte subpopulation, which emerged during human liver regeneration, and a corollary subpopulation in a mouse model of acetaminophen-induced liver regeneration.
Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.
